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The Endothelin1 Reporter Collection

SwitchGear Genomics offers genome-wide panels of transfection-ready, cell-based reporter assays including specific panels of endothelin1-relevant promoter reporters and endothelin1-relevant UTR reporters allowing you to accurately quantify transcriptional regulation, transcript stability, and translational efficiency of genes in the endothelin1 signaling pathway. Uncover miRNA function and the effects of transcription binding in the full endothelin1 pathway of genes.

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Endothelin1 Pathway Products

Endothelin1 Canonical Pathway diagram | Click on the image for a larger view.

SwitchGear Genomics acknowledges Ingenuity Systems®, Inc. www.ingenuity.com for the biological pathway diagram and supporting content.

SwitchGear offers promoter and UTR reporters for studying transcript regulation and stability. Custom pricing is available for orders of 10 or more constructs. Contact us!  Our Endothelin1 Promoter Reporter Collection enables you to quantify promoter induction and assess transcriptional activation driven by specific transcription factors. Our Endothelin1 UTR Reporter Collection allows you to quantify the 3′UTR impact on transcript stability under specific conditions (e.g. in the presence of an miRNA).Or search SwitchDB for specific miRNA candidates. View our genome-wide collection of promoter and UTR products in our online catalog, SwitchDB.

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Applications

The SwitchGear collection of Endothelin1-relevant promoter reporters allows you to:

• Understand the mechanisms by which the pathway of genes is induced or repressed
• Quantify the functional consequences of transcription factor binding – while many other technologies give a qualitative view of transcription factor presence, our promoter reporter assays quantify the effects of transcription factor binding.
• Confirm data from ChIP-chip or ChIP-sequencing experiments
• Measure the effect of sequence variants and mutagenesis on promoter function
• Screen for promoter activation in the full pathway under a multitude of conditions

See Promoter Reporter Collection for general information.

The SwitchGear collection of Endothelin1-relevant 3′UTR reporters allows you to:

• Quantify the functional role of UTRs and miRNAs in post-transcriptional gene regulation under a multitude of conditions
• Validate expression data and computational predictions with miRNA functional studies
• Measure the effect of sequence variants and mutagenesis on 3′UTR function
• Screen for UTR and miRNA function in the full pathway

See UTR Reporter Collection for general information. Or search SwitchDB for specific miRNA candidates.