p38 MAPK Reporter Collection

P38 mitogen-activated protein kinases play critical roles in cellular stress response, cell differentiation, and apoptosis. Understanding the mechanisms of gene regulation in the p38 MAPK pathways provides key insights into various diseases and is important for potential therapeutic development. SwitchGear Genomics offers genome-wide panels of transfection-ready, cell-based reporter assays including specific panels of p38 MAPK-relevant promoter reporters and p38 MAPK-relevant UTR reporters allowing you to accurately quantify the effects of transcription factor binding and the functional roles of UTRs and miRNAs in the p38 MAPK pathway of genes. Measure transcriptional regulation, transcript stability, and translational efficiency of genes in the p38 MAPK-mediated pathways.

p38 MAPK Pathway Products

p38 MAPK Canonical Pathway diagram | Click on the image for a larger view.

SwitchGear Genomics acknowledges Ingenuity Systems®, Inc. www.ingenuity.com for the biological pathway diagram and supporting content.

SwitchGear offers promoter and UTR reporters for studying translational efficiency and transcript regulation and stability.Custom pricing is available for orders of 10 or more constructs. Contact us!

Our p38 MAPK Promoter Reporter Collection enables you to quantify promoter induction and assess transcriptional activation driven by specific transcription factors in the p38 MAPK pathway.
Our p38 MAPK UTR Reporter Collection allows you to quantify 3′UTR impact on transcript stability and uncover miRNA function. Or search SwitchDB for specific miRNA candidates.

View our genome-wide collection of promoter and UTR products in our online catalog, SwitchDB.

Applications

The SwitchGear collection of p38 MAPK-relevant promoter reporters allows you to:

Understand the mechanisms by which the p38 MAPK pathway of genes are induced or repressed
Quantify the functional consequences of transcription factor binding – while many other technologies give a qualitative view of transcription factor presence, our promoter reporter assays quantify the effects of transcription factor binding.
Confirm data from ChIP-chip or ChIP-sequencing experiments
Measure the effect of sequence variants and mutagenesis on promoter function
Screen for promoter activation in the full p38 MAPK pathway under a multitude of conditions

See Promoter Reporter Collection for general information.

The SwitchGear collection of p38 MAPK-relevant 3′UTR reporters allows you to:

Quantify the functional role of UTRs and miRNAs in post-transcriptional gene regulation under a multitude of conditions
Validate expression data and computational predictions with miRNA functional studies
Measure the effect of sequence variants and mutagenesis on 3′UTR function
Screen for UTR and miRNA function in the full p38 MAPK pathway

See UTR Reporter Collection for general information. Or search SwitchDB for specific miRNA candidates.

The SwitchGear Advantage

QUANTITATIVE
Quantify miRNA impact or consequences of transcription factor binding through highly quantitative luciferase activity.

COMPREHENSIVE AND VALIDATED
Choose from Switchgear’s catalog of 7,000 sequence-verified UTR constructs and 10,000 promoter constructs.

SIMPLE AND QUICK
Perform your experiments today through a simple transfection of our UTR or promoter constructs. No cloning or DNA preparation required.