Reporter Collection for Insulin Receptor Targets

SwitchGear Genomics offers genome-wide panels of transfection-ready, cell-based reporter assays including specific panels of insulin receptor-relevant promoter reporters and insulin receptor-relevant UTR reporters allowing you to accurately quantify the effects of transcription factor binding and the roles of UTRs and miRNAs in the insulin receptor-mediated pathway of genes. Quantify transcriptional regulation, transcript stability, and translational efficiency of genes in the insulin receptor-mediated pathways.

Insulin Receptor-Mediated Pathway Products

Insulin Receptor Canonical Pathway diagram | Click on the image for a larger view.

SwitchGear Genomics acknowledges Ingenuity Systems®, Inc. www.ingenuity.com for the biological pathway diagram and supporting content.

SwitchGear offers promoter and UTR reporters for studying translational efficiency and transcript regulation and stability.Custom pricing is available for orders of 10 or more constructs. Contact us!

Our Insulin Receptor Promoter Reporter Collection enables you to quantify promoter induction and assess transcriptional activation driven by specific transcription factors for genes in the insulin receptor-mediated pathway.
Our Insulin Receptor UTR Reporter Collection allows you to quantify 3′UTR impact on transcript stability and uncover miRNA function in the insulin receptor-mediated pathway. Or search SwitchDB for specific miRNA candidates.

View our genome-wide collection of promoter and UTR products in our online catalog, SwitchDB.

Applications

The SwitchGear collection of insulin receptor-relevant promoter reporters allows you to:

Understand the mechanisms by which the insulin receptor mediated pathway of genes is induced or repressed
Quantify the functional consequences of transcription factor binding – while many other technologies give a qualitative view of transcription factor presence, our promoter reporter assays quantify the effects of transcription factor binding.
Confirm data from ChIP-chip or ChIP-sequencing experiments
Measure the effect of sequence variants and mutagenesis on promoter function
Screen for promoter activation in the full insulin receptor mediated pathway of genes under a multitude of conditions

See Promoter Reporter Collection for general information.

The SwitchGear collection of insulin receptor-relevant 3′UTR reporters allows you to:

Quantify the functional role of UTRs and miRNAs in post-transcriptional gene regulation under a multitude of conditions
Validate expression data and computational predictions with miRNA functional studies
Measure the effect of sequence variants and mutagenesis on 3′UTR function
Screen for UTR and miRNA function in the full insulin receptor-mediated pathway

See UTR Reporter Collection for general information. Or search SwitchDB for specific miRNA candidates.

The SwitchGear Advantage

QUANTITATIVE
Quantify miRNA impact or consequences of transcription factor binding through highly quantitative luciferase activity.

COMPREHENSIVE AND VALIDATED
Choose from Switchgear’s catalog of 7,000 sequence-verified UTR constructs and 10,000 promoter constructs.

SIMPLE AND QUICK
Perform your experiments today through a simple transfection of our UTR or promoter constructs. No cloning or DNA preparation required.