Serotonin Reporter Collection

Understanding gene regulation in the serotonin signaling pathway can reveal key insights and potential therapeutic agents for various neurological diseases, psychiatric disorders, general metabolism, pulmonary hypertension, bone formation, cellular growth, and cellular proliferation. SwitchGear Genomics offers genome-wide panels of transfection-ready, cell-based reporter assays including specific panels of serotonin-relevant promoter reporters and serotonin-relevant UTR reporters allowing you to accurately quantify transcriptional regulation, transcript stability, and translational efficiency in the serotonin signaling pathway. Our reporters uncover miRNA function and the effects of transcription factor binding in the full serotonin signaling pathway of genes.

 

Serotonin Pathway Products

Serotonin Canonical Pathway diagram | Click on the image for a larger view.
serotonin-receptor
SwitchGear Genomics acknowledges Ingenuity Systems®, Inc. www.ingenuity.com for the biological pathway diagram and supporting content.
SwitchGear offers promoter and UTR reporters for studying transcript regulation and stability. Custom pricing is available for orders of 10 or more constructs. Contact us! 

  • Our Serotonin Promoter Reporter Collection enables you to quantify promoter induction and assess transcriptional activation driven by specific transcription factors in the serotonin signaling pathway of genes.
  • Our Serotonin UTR Reporter Collection allows you to quantify 3′UTR impact on translational efficiency and transcript stability and uncover miRNA function in the serotonin signaling pathway of genes.

View our genome-wide collection of promoter and UTR products in our online catalog, SwitchDB.
 

Applications

The SwitchGear collection of serotonin-relevant promoter reporters allows you to:

  • Understand the mechanisms by which the serotonin pathway of genes is induced or repressed
  • Quantify the functional consequences of transcription factor binding – while many other technologies give a qualitative view of transcription factor presence, our promoter reporter assays quantify the effects of transcription factor binding.
  • Confirm data from ChIP-chip or ChIP-sequencing experiments
  • Measure the effect of sequence variants and mutagenesis on promoter function
  • Screen for promoter activation in the full serotonin pathway under a multitude of conditions

See Promoter Reporter Collection for general information.

The SwitchGear collection of serotonin-relevant 3′UTR reporters allows you to:

  • Quantify the functional role of UTRs and miRNAs in post-transcriptional gene regulation under a multitude of conditions
  • Validate expression data and computational predictions with miRNA functional studies
  • Measure the effect of sequence variants and mutagenesis on 3′UTR function
  • Screen for UTR and miRNA function in the full serotonin pathway

See UTR Reporter Collection for general information.

 

The SwitchGear Advantage

QUANTITATIVE
Quantify miRNA impact or consequences of transcription factor binding through highly quantitative luciferase activity.

COMPREHENSIVE AND VALIDATED
Choose from Switchgear’s catalog of 7,000 sequence-verified UTR constructs and 10,000 promoter constructs.

SIMPLE AND QUICK
Perform your experiments today through a simple transfection of our UTR or promoter constructs. No cloning or DNA preparation required.