The SwitchGear TGF-beta Pathway Panel
As constitutive activation of the TGF-beta/SMAD pathways can lead to tumor growth, irregular embryogenesis and various other diseases, modulating TGF-beta signaling may confer therapeutic benefit for many physiological disorders. SwitchGear Genomics offers genome-wide panels of transfection-ready, cell-based reporter assays including specific panels of TGF-beta/SMAD promoter reporters and TGF-beta/SMAD UTR reporters to allow you to accurately quantify transcriptional regulation and translational efficiency in the TGF-beta pathways.
Products: TGF-beta/SMAD reporter assays
Click image for a larger view of the TGF-beta pathway.
|
SwitchGear offers genome-wide, assay-ready promoter and UTR reporters for studying transcript regulation and stability, including specific panels for TGF-beta/SMAD. Please note that custom pricing is available for orders of 10 or more constructs. Contact us for more information.
|
View our genome-wide collection of promoter and UTR products in our online catalog, SwitchDB.
Applications
The SwitchGear collection of TGF-beta-relevant promoter reporters allows you to:
- Understand the mechanisms by which the TGF-beta signaling pathway of genes is induced or repressed
- Quantify the functional consequences of transcription factor binding – while many other technologies give a qualitative view of transcription factor presence, our promoter reporter assays quantify the effects of transcription factor binding.
- Confirm data from ChIP-chip or ChIP-sequencing experiments
- Measure the effect of sequence variants and mutagenesis on promoter function
- Screen for promoter activation in the full TGF-beta signaling pathway under a multitude of conditions
See Promoter Reporter Collection for general information.
The SwitchGear collection of TGF-beta-relevant 3′UTR reporters allows you to:
- Quantify the functional role of UTRs and miRNAs in post-transcriptional gene regulation under a multitude of conditions
- Validate expression data and computational predictions with miRNA functional studies
- Measure the effect of sequence variants and mutagenesis on 3′UTR function
- Screen for UTR and miRNA function in the full TGF-beta pathway
See UTR Reporter Collection for general information. Or search SwitchDB for specific miRNA candidates.
The SwitchGear Advantage
- Quantitative: Quantify miRNA impact or consequences of transcription factor binding through highly quantitative luciferase activity.
- Comprehensive and validated: Choose from Switchgear’s catalog of 7,000 sequence-verified UTR constructs and 10,000 promoter constructs.
- Simple and quick: Perform your experiments today through a simple transfection of our UTR or promoter constructs. No cloning or DNA preparation required.

