The Apoptosis Signaling Pathway Reporter Collection
Understanding the regulation of apoptosis is critical in understanding the mechanisms of various pathologic conditions including cancer, stroke, autoimmune disorders, and neurodegenerative conditions.
SwitchGear Genomics offers genome-wide panels of transfection-ready, cell-based reporter assays including specific panels of Apoptosis promoter reporters and Apoptosis UTR reporters to allow you to accurately quantify transcriptional regulation, transcript stability, and translational efficiency in the apoptosis signaling pathway.
Products: Reporter assays for Apoptosis
Click image for a larger view of the apoptosis pathway.
|
SwitchGear offers genome-wide, assay-ready promoter and UTR reporters for studying transcript regulation and stability, including specific panels for studying apoptosis. Custom pricing is available for 10 or more constructs from these collections. Contact us!
|
View our genome-wide collection of promoter and UTR products in our online catalog, SwitchDB.
Applications
The SwitchGear collection of promoter reporters allows you to:
- Understand the mechanisms by which the apoptosis signaling pathway of genes is induced or repressed
- Quantify the functional consequences of transcription factor binding – while many other technologies give a qualitative view of transcription factor presence, our promoter reporter assays quantify the effects of transcription factor binding.
- Confirm data from ChIP-chip or ChIP-sequencing experiments
- Measure the effect of sequence variants and mutagenesis on promoter function
- Screen for promoter activation in the full apoptosis signaling pathway under a multitude of conditions
See Promoter Reporter Collection for general information.
The SwitchGear collection of apoptosis-relevant 3′UTR reporters allows you to:
- Quantify the functional role of UTRs and miRNAs in post-transcriptional gene regulation under a multitude of conditions
- Validate expression data and computational predictions with miRNA functional studies
- Measure the effect of sequence variants and mutagenesis on 3′UTR function
- Screen for UTR and miRNA function in the full apoptosis signaling pathway
See UTR Reporter Collection for general information.
The SwitchGear Advantage
QUANTITATIVE
Quantify miRNA impact or consequences of transcription factor binding through highly quantitative luciferase activity.
COMPREHENSIVE AND VALIDATED
Choose from Switchgear’s catalog of 7,000 sequence-verified UTR constructs and 10,000 promoter constructs.
SIMPLE AND QUICK
Perform your experiments today through a simple transfection of our UTR or promoter constructs. No cloning or DNA preparation required.