The Parkinson’s Disease Pathway Reporter Collection

Understanding the genetic signature of Parkinson’s disease, the progressive neurological disorder that affects motor control, has been a focus of many recent studies. Mutations in the genes PARK2, PARK7, PINK1, LRRK2, and SNCA have been linked to Parkinson’s. In addition, alterations in the GBA, SNCAIP, or UCHL1 genes have been implicated in increasing the risk of developing Parkinson’s disease. Studies have also have revealed other various genetic changes that potentially both reduce or increase the risk of developing the disease. Gaining insight into the mechanisms of gene regulation in Parkinson’s disease is key to understanding the genetic profile of this debilitating disease.

SwitchGear Genomics offers genome-wide panels of transfection-ready, cell-based reporter assays including specific panels of Parkinson’s promoter reporters and Parkinson’s UTR reporters allowing you to accurately quantify transcriptional regulation, transcript stability, and translational efficiency in the Parkinson’s genetic pathway.

Products: Reporter assays for Parkinson’s Disease

Click image for a larger view of the Parkinson’s pathway.

SwitchGear Genomics acknowledges Ingenuity Systems®, Inc. www.ingenuity.com for the biological pathway diagram and supporting content.

SwitchGear offers genome-wide, assay-ready promoter and UTR reporters for studying transcript regulation and stability, including specific panels for studying the Parkinson’s pathway. Custom pricing is available for 10 or more constructs. Contact Us!

Our Parkinson’s Promoter Reporter Collection enables you to quantify promoter induction and more fully assess transcriptional activation driven by specific transcription factors.
Our Parkinson’s UTR Reporter Collection allows you to quantify 3′UTR impact on transcript stability and translational efficiency and study miRNA function. Also, you can search SwitchDB for specific miRNAs.

View our genome-wide collection of promoter and UTR products in our online catalog, SwitchDB.

Applications

The SwitchGear collection of Parkinson’s-relevant promoter reporters allows you to:

Understand the mechanisms by which the Parkinson’s signaling pathway of genes is induced or repressed
Quantify the functional consequences of transcription factor binding – while many other technologies give a qualitative view of transcription factor presence, our promoter reporter assays quantify the effects of transcription factor binding.
Confirm data from ChIP-chip or ChIP-sequencing experiments
Measure the effect of sequence variants and mutagenesis on promoter function
Screen for promoter activation in the full Parkinson’s pathway under a multitude of conditions

See Promoter Reporter Collection for general information.

The SwitchGear collection of Parkinson’s-relevant 3′UTR reporters allows you to:

Quantify the functional role of UTRs and miRNAs in post-transcriptional gene regulation under a multitude of conditions
Validate expression data and computational predictions with miRNA functional studies
Measure the effect of sequence variants and mutagenesis on 3′UTR function
Screen for UTR and miRNA function in the full Parkinson’s pathway

See UTR Reporter Collection for general information.

The SwitchGear Advantage

QUANTITATIVE
Quantify miRNA impact or consequences of transcription factor binding through highly quantitative luciferase activity.

COMPREHENSIVE AND VALIDATED
Choose from Switchgear’s catalog of 7,000 sequence-verified UTR constructs and 10,000 promoter constructs.

SIMPLE AND QUICK
Perform your experiments today through a simple transfection of our UTR or promoter constructs. No cloning or DNA preparation required.