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Custom Cloning
Use our custom service to clone any fragment from the human, mouse, or rat genome into any LightSwitch™ luciferase reporter vector (promoter, 3′UTR, long-range element, 5′UTR).

Custom Mutagenesis
Use our site-directed mutagenesis service to create any sequence variant from any existing LightSwitch™ reporter vector. Mutations may be up to 5 consecutive bases.

Pathway Screening Services Use our expert, cell-based screening service to measure the effects of your compounds on a variety of biological pathways. Our unique collection of 48 validated human promoter reporter vectors measure gene expression changes associated with 11 disease-related biological pathways. Ideal for secondary screening, lead optimization, off-target analysis, and dose-response.

Sequence Variant Assay Services Understand the functional impact of sequence variation on promoter or 3′UTR activity. Our services include creating promoter or 3′UTR sequence variants and conducting transient reporter assays in living cells to quantify the effects of the sequence changes.

miRNA Target Validation Service SwitchGear Genomics offers a full screening service to validate the 3′UTR targets of your miRNAs. Using our genome-wide GoClone® collection of human 3′UTRs cloned into the optimized LightSwitch™ luciferase reporter vector, our in-house experts can validate the targets of your miRNAs of interest with our high-throughput cell-based assay.