LightSwitch™ Pathway Reporter Stable Cell Lines
SwitchGear now offers the largest collection of pathway reporter stable cell lines, all using the LightSwitch Reporter System!
Each LightSwitch Pathway Reporter Cell Line contains a stably integrated LightSwitch reporter construct with a human regulatory element that has been validated to drive expression of the optimized RenSP luciferase reporter gene, which delivers exceptional sensitivity and dynamic range when used with LightSwitch Luciferase Assay Reagents. This greatly simplifies the task of measuring the response of specific pathways to treatment with various compounds or growth conditions. Custom services are also available for creating custom reporter cell lines.
All cell lines must be used with LightSwitch Assay Reagents.
| Prod ID | Product Name | Pathway | Cell Type | |
| D717678L | Control2_HT1080 | Housekeeping control | HT1080 |  |
| C717678L | Control2_HEPG2 | Housekeeping control | HEPG2 | |
| D900030L | BMP_HT1080 | Bone morphogenesis | HT1080 | |
| D711010L | SREBP_1_HT1080 | Cholesterol | HT1080 | |
| C711010L | SREBP_1_HEPG2 | Cholesterol | HEPG2 | |
| C714555L | AhR_2_HEPG2 | Dioxin, Tox | HEPG2 | |
| D718021L | p53_HT1080 | DNA damage, apoptosis | HT1080 | |
| D900015L | GR_HT1080 | Glucocorticoid | HT1080 | |
| D900017L | HSF1_HT1080 | Heat shock | HT1080 | |
| D721613L | HIF1a_1_HT1080 | Hypoxia | HT1080 | |
| D721709L | NFkB_1_HT1080 | Inflammation | HT1080 | |
| D722879L | NFkB_2_HT1080 | Inflammation | HT1080 | |
| D900018L | NFkB_3_HT1080 | Inflammation | HT1080 | |
| D722854L | STAT_HT1080 | Interferon | HT1080 | |
| C722854L | STAT_HEPG2 | Interferon | HEPG2 | |